The Influence of Urethane in the Production of Glycosuria in Rabbits after the In- Travenous Injection of Adrenalin

The vast accumulation of literature relative to adrenalin glycosuria contains very few records of attempts to demonstrate a quantitative relationship between adrenalin administration and sugar elimination. For the most part investigators have been content with the knowledge that a certain quantity of adrenalin injected subcutaneously or intraperitoneally almost invariably causes the appearance in the urine of significant quantities of dextrose. Moreover, it has been generally accepted that adrenalin given by mouth entirely fails to provoke glycosuria and that the intraperitoneal administration gives rise to a greater sugar excretion than the introduction of the drug directly into the circulation. What relationship exists between the quantity of adrenalin injected and the sugar eliminated, and how this relation may vary with change in the manner of adrenalin introduction are questions of some importance since adrenalin effects are constantly employed in the study of problems having a far reaching significance. Perhaps the most suggestive investigation in this particular direction is the recent communication of Ritsmannl. He has shown that the degree of glycosuria is dependent upon the quantity of adrenalin present in the blood at any given moment. So long as adrenalin is present in the blood sugar in the urine is in order but